Collaborative Computational Project
for Electron cryo-Microscopy

Proceedings cover
Proceedings of the CCP-EM Spring Symposium, Acta Cryst D, June 2017
CCP-EM is supported by

For further details, please contact Martyn Winn.

Instruct logo
CCP-EM is a partner in the Instruct Computational Centre (CCISB).
West-Life logo
CCP-EM is a partner in West-Life: Structures for Life.

The Collaborative Computational Project for electron cryo-microscopy (CCP-EM) supports users and developers in biological EM. The three principal aims are:

  • Build a UK community for computational aspects of cryo-EM. Provide a focus for the cryo-EM community to interact with CCP4/CCPBioSim/CCPN, and the broader international community.
  • Support the users of software for cryo-EM through dissemination of information on available software, and directed training.
  • Support for software developers including porting, testing, and distribution of software.
The creation of CCP-EM was supported through a 3-year Partnership Grant from the MRC and continued support is provided through a new 5-year Partnership Grant from the MRC.

There is a mailing list for CCP-EM (supported by JISCMail). The home page for the list is at To subscribe to the list, click on "Subscribe or Unsubscribe" on this page. Once you have an account, you can manage your list preference from this page. You can also search the CCP-EM archive from here. Note that the list is PUBLIC, meaning that the archives can be accessed by anyone, and are indexed by search engines. For more details, see the JISCmail Service Policies page.

Follow us on Twitter @ccp_em.

Email us at


CCP-EM software suite v1.5 is now available! See Downloads page.

We are pleased to announce a three day online symposium on “Cryo-EM Validation in the Age of SARS-CoV-2: Methods, Tools and Applications” which will take place 18, 19 & 20 November 2020.

Kailash Ramlaul, Colin M. Palmer, Christopher H.S. Aylett (2019) “Mitigating Local Over-fitting During Single Particle Reconstruction with SIDESPLITTER” bioRxiv: 874081

The Spring Symposium lectures are now available on YouTube.

Cryo-EM with Relion, NVIDIA webinar on Relion.

We are pleased to announce that the first Chair of CCP-EM is Peter Rosenthal (Francis Crick Institute), and the first Deputy Chair is Neil Ranson (Leeds).

Main references

Recent developments in the CCP-EM software suite T. Burnley, C.M. Palmer and M.D Winn, Acta Cryst., D73, 469 - 477 (2017)

Collaborative Computational Project for Electron cryo-Microscopy C. Wood, T. Burnley, A. Patwardhan, S. Scheres, M. Topf, A. Roseman and M.D Winn, Acta Cryst., D71, 123 - 126 (2015)